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FDA Drug Safety Communication: FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women

December 14, 2016 | Food and Drug Administration

The U.S. Food and Drug Administration (FDA) is warning that repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women during their third trimester may affect the development of children's brains …

EDITOR'S NOTE: These concerns are part of why Expanesthetics is working toward new general anesthetic drugs with novel mechanisms of action.

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General Anesthesia in Peds May Affect Brain Development and IQ Scores

September 1, 2016 | Anesthesiology News

A recent study published in Pediatrics suggests that children who received anesthesia before the age of 4 had lower IQ scores than a comparator group who did not receive anesthesia. It is important to remember that surgery and anesthesia are safe for kids, but Dr. Andres Loepke and Dr. Andrew Davidson are among those calling for a bigger discussion and understanding of the risks.

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Lancet Commission on Global Surgery says a third of deaths worldwide due to lack of safe surgery, anesthesia

April 28, 2015 | The Globe and Mail

The Lancet Commission on Global Surgery released a report saying roughly a third of deaths worldwide are due to a lack of surgical access. With an estimated 5 billion people who lack access to safe and affordable surgical and anesthesia care and nearly 17 million lives lost due to surgical conditions in 2010, the report recommends a scaling up of the surgical and anesthesia workforce in fifteen years to double what it is today. The report in its entirety can be viewed here.

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Neurotoxicity of General Anesthetics makes it into JAMA

April 21, 2015 | Journal of the American Medical Association

From zebrafish to monkeys, there is an increasing body of evidence suggesting commonly used general anesthetics are neurotoxic in juvenile animal studies. The translatability of these studies to the human population is still unclear, as currently available studies in young children are not sufficiently robust to either confirm the results seen in animal studies or 'provide assurance of safety.' What is clear is the US FDA is taking active steps to assess and understand the neurotoxic effects of general anesthetics to the developing brain.

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